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Article

The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component.

Molecular biology of the cell - 1 Nov 2005

Murakami Yoshiko, Siripanyaphinyo Uamporn, Hong Yeongjin, Tashima Yuko, Maeda Yusuke, Kinoshita Taroh

Abstract excerpt

Biosynthesis of glycosylphosphatidylinositol (GPI) is initiated by an unusually complex GPI-N-acetylglucosaminyltransferase (GPI-GnT) consisting of at least six proteins. Here, we report that human GPI-GnT requires another component, termed PIG-Y, a 71 amino acid protein with two transmembrane domains. The Burkitt lymphoma cell line Daudi, severely defective in the surface expression of GPI-anchored proteins, was...

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Identifiers

PMID: 16162815
DOI: 10.1091/mbc.e05-08-0743
PMCID: PMC1266422

Genes

GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component.PMID 16162815Read ↗

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