Article
In vivo pharmacodynamic efficacy of gatifloxacin against Streptococcus pneumoniae in an experimental model of pneumonia: impact of the low levels of fluoroquinolone resistance on the enrichment of resistant mutants.
The Journal of antimicrobial chemotherapy - 1 Sept 2004
Croisier Delphine, Etienne Manuel, Piroth Lionel, Bergoin Emilie, Lequeu Catherine, Portier Henri, Chavanet Pascal
Abstract excerpt
OBJECTIVES: To investigate the impact of low levels of fluoroquinolone resistance on the emergence of resistant mutants, we examined the mutant selection window (MSW) hypothesis in experimental pneumonia in rabbits infected with pneumococci with various susceptibility levels to fluoroquinolones and treated with gatifloxacin using a human-like regimen (equivalent to 400 mg once daily). The MSW corresponds to the...
Topics
- Animals
- Anti-Infective Agents
- Area Under Curve
- DNA Gyrase
- DNA Topoisomerase IV
- DNA, Bacterial
- Disease Models, Animal
- Drug Resistance, Bacterial
- Fluoroquinolones
- Gatifloxacin
- Humans
- Male