Article
[Mutation window for the "pneumococcus-fluoroquinolone" couple. Contribution of experimental models].
Medecine et maladies infectieuses - 1 Jan 2000
Chavanet P, Croisier D
Abstract excerpt
Low-level resistance to fluoroquinolones (in vitro susceptible but with topoisomerase mutation, parC) is currently rare among pneumococci in France. However, this resistance is more frequently observed in previously exposed patients and therapeutic failure has been reported. These issues were investigated by using a humanized model of experimental pneumonia induced by pneumococci exhibiting this low-level...
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