Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant selection window in levofloxacin and moxifloxacin treatments of experimental pneumococcal pneumonia in a rabbit model of human therapy.

Antimicrobial agents and chemotherapy - 1 May 2004

Croisier Delphine, Etienne Manuel, Bergoin Emilie, Charles Pierre-Emmanuel, Lequeu Catherine, Piroth Lionel, Portier Henri, Chavanet Pascal

Abstract excerpt

For some pneumococci the fluoroquinolone MICs are low but the mutant prevention concentrations (MPCs) are high; this difference defines in vitro the mutant selection window (MSW). We investigated in vivo the bacterial reduction and the occurrence of resistant mutants with moxifloxacin (MFX; 400 mg once daily) or levofloxacin (LVX; 500 mg twice daily) in treatments similar to those in humans with experimental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Infective Agents
Share to Aza Compounds

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluoroquinolones

Share to Levofloxacin

Share to Moxifloxacin

Share to Ofloxacin

Share to Pneumonia, Pneumococcal

Share to Quinolines

Source

Open in PubMed Open full text

Identifiers

PMID: 15105123
DOI: 10.1128/AAC.48.5.1699-1707.2004
PMCID: PMC400524

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant selection window in levofloxacin and moxifloxacin treatments of experimental pneumococcal pneumonia in a rabbit model of human therapy.PMID 15105123Read ↗

In vivo pharmacodynamic efficacy of gatifloxacin against Streptococcus pneumoniae in an experimental model of pneumonia: impact of the low levels of fluoroquinolone resistance on the enrichment of resistant mutants.Semantic proximity Read ↗

Efficacy and pharmacodynamics of simulated human-like treatment with levofloxacin on experimental pneumonia induced with penicillin-resistant pneumococci with various susceptibilities to fluoroquinolones.Semantic proximity Read ↗

Effect of low-level resistance on subsequent enrichment of fluoroquinolone-resistant Streptococcus pneumoniae in rabbits.Semantic proximity Read ↗

Emergence of resistant Streptococcus pneumoniae in an in vitro dynamic model that simulates moxifloxacin concentrations inside and outside the mutant selection window: related changes in susceptibility, resistance frequency and bacterial killing.Semantic proximity Read ↗

A pharmacodynamic approach to antimicrobial activity in serum and epithelial lining fluid against in vivo-selected Streptococcus pneumoniae mutants and association with clinical failure in pneumonia.Semantic proximity Read ↗

In vivo validation of the mutant selection window hypothesis with moxifloxacin in a murine model of tuberculosis.Semantic proximity Read ↗

Efficacy and potential for resistance selection of antipseudomonal treatments in a mouse model of lung infection by hypermutable Pseudomonas aeruginosa.Semantic proximity Read ↗

Activities of mutant prevention concentration-targeted moxifloxacin and levofloxacin against Streptococcus pneumoniae in an in vitro pharmacodynamic model.Semantic proximity Read ↗

[Mutation window for the "pneumococcus-fluoroquinolone" couple. Contribution of experimental models].Semantic proximity Read ↗

Emergence and spread of antibiotic resistance following exposure to antibiotics.Semantic proximity Read ↗

Analysis of the mutant selection window and killing of Mycoplasma hyopneumoniae for doxycycline, tylosin, danofloxacin, tiamulin, and valnemulin.Semantic proximity Read ↗

Mutant prevention concentration and mutant selection window for 10 antimicrobial agents against Rhodococcus equi.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.