Article
A pharmacodynamic approach to antimicrobial activity in serum and epithelial lining fluid against in vivo-selected Streptococcus pneumoniae mutants and association with clinical failure in pneumonia.
The Journal of antimicrobial chemotherapy - 1 Aug 2006
Alou Luis, Giménez María-José, Sevillano David, Aguilar Lorenzo, Cafini Fabio, Echeverría Olatz, Pérez-Trallero Emilio, Prieto José
Abstract excerpt
OBJECTIVES: Emergence of resistance may be prevented by killing both the parental infecting strain and subsequent less susceptible step-mutants. The present study analyses eradication and resistance selection in Streptococcus pneumoniae with moxifloxacin, levofloxacin and azithromycin, using a parental serotype 3 clinical strain (strain A) and its correspondent step-mutant derivatives resistant to these...
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