Article
Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy.
The Journal of clinical investigation - 1 Jul 2003
Jumbe Nelson, Louie Arnold, Leary Robert, Liu Weiguo, Deziel Mark R, Tam Vincent H, Bachhawat Reetu, Freeman Christopher, Kahn James B, Bush Karen, Dudley Michael N, Miller Michael H, Drusano George L
Abstract excerpt
The worldwide increase in the prevalence of multi-antibiotic-resistant bacteria has threatened the physician's ability to provide appropriate therapy for infections. The relationship between antimicrobial drug concentration and infecting pathogen population reduction is of primary interest. Using data derived from mice infected with the bacterium Pseudomonas aeruginosa and treated with a fluoroquinolone...
Topics
- Animals
- Anti-Bacterial Agents
- Dose-Response Relationship, Drug
- Drug Resistance, Microbial
- Drug Resistance, Multiple
- Female
- Kinetics
- Mice
- Mice, Inbred ICR
- Models, Theoretical