Article
Emergence and spread of antibiotic resistance following exposure to antibiotics.
FEMS microbiology reviews - 1 Sept 2011
Cantón Rafael, Morosini María-Isabel
Abstract excerpt
Within a susceptible wild-type population, a small fraction of cells, even <10(-9) , is not affected when challenged by an antimicrobial agent. This subpopulation has mutations that impede antimicrobial action, allowing their selection during clinical treatment. Emergence of resistance occurs in the frame of a selective compartment termed a mutant selection window (MSW). The lower margin corresponds to the...
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