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Article

Effect of low-level resistance on subsequent enrichment of fluoroquinolone-resistant Streptococcus pneumoniae in rabbits.

The Journal of infectious diseases - 15 Oct 2004

Etienne Manuel, Croisier Delphine, Charles Pierre-Emmanuel, Lequeu Catherine, Piroth Lionel, Portier Henri, Drlica Karl, Chavanet Pascal

Abstract excerpt

BACKGROUND: We measured the effect of low-level fluoroquinolone resistance in Streptococcus pneumoniae on the development of high-level resistance within the context of the mutant selection window. METHODS: Rabbits infected with S. pneumoniae were treated with ciprofloxacin or moxifloxacin concentrations that simulated pharmacokinetics in treated humans; bacteria obtained from lungs were examined for...

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PMID: 15378440
DOI: 10.1086/423853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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