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Article

Activity of gemifloxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model.

Antimicrobial agents and chemotherapy - 1 Mar 2005

Azoulay-Dupuis E, Bédos J P, Mohler J, Moine P, Cherbuliez C, Peytavin G, Fantin B, Köhler T

Abstract excerpt

Gemifloxacin is a novel fluoronaphthyridone quinolone with enhanced in vitro activity against Streptococcus pneumoniae. We investigated the activities of gemifloxacin and trovafloxacin, their abilities to select for resistance in vitro and in vivo, and their efficacies in a mouse model of acute pneumonia. Immunocompetent Swiss mice were infected with 10(5) CFU of a virulent, encapsulated S. pneumoniae strain,...

Topics

Animals
Area Under Curve
Drug Resistance, Bacterial
Fluoroquinolones
Gemifloxacin
Mice
Microbial Sensitivity Tests
Mutation
Naphthyridines
Pneumonia, Pneumococcal
Streptococcus pneumoniae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15728901
DOI: 10.1128/AAC.49.3.1046-1054.2005
PMCID: PMC549237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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