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Article

Selection of quinolone resistance in Streptococcus pneumoniae exposed in vitro to subinhibitory drug concentrations.

The Journal of antimicrobial chemotherapy - 1 Nov 2007

Avrain Laetitia, Garvey Mark, Mesaros Narcisa, Glupczynski Youri, Mingeot-Leclercq Marie-Paule, Piddock Laura J V, Tulkens Paul M, Vanhoof Raymond, Van Bambeke Françoise

Abstract excerpt

OBJECTIVES: Does exposure to subinhibitory concentrations of quinolones favour overexpression of efflux pumps or selection of target site mutations? METHODS: ATCC 49,619 (fully susceptible) and SP32 (clinical isolate with PmrA-mediated efflux and mutation in ParE) were exposed for 24 h in broth to ciprofloxacin, levofloxacin, moxifloxacin or garenoxacin at concentrations of 0.5x the MIC, with daily re-adjustments...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17693451
DOI: 10.1093/jac/dkm292

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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