Article
Selection of quinolone resistance in Streptococcus pneumoniae exposed in vitro to subinhibitory drug concentrations.
The Journal of antimicrobial chemotherapy - 1 Nov 2007
Avrain Laetitia, Garvey Mark, Mesaros Narcisa, Glupczynski Youri, Mingeot-Leclercq Marie-Paule, Piddock Laura J V, Tulkens Paul M, Vanhoof Raymond, Van Bambeke Françoise
Abstract excerpt
OBJECTIVES: Does exposure to subinhibitory concentrations of quinolones favour overexpression of efflux pumps or selection of target site mutations? METHODS: ATCC 49,619 (fully susceptible) and SP32 (clinical isolate with PmrA-mediated efflux and mutation in ParE) were exposed for 24 h in broth to ciprofloxacin, levofloxacin, moxifloxacin or garenoxacin at concentrations of 0.5x the MIC, with daily re-adjustments...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Drug Resistance, Bacterial
- Gene Expression Regulation, Bacterial
- Microbial Sensitivity Tests
- Mutation
- Quinolones
- Reserpine
- Selection, Genetic