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Article

Cys mutants in functional regions of Sticholysin I clarify the participation of these residues in pore formation.

Toxicon : official journal of the International Society on Toxinology - 1 Jul 2011

Valle A, López-Castilla A, Pedrera L, Martínez D, Tejuca M, Campos J, Fando R, Lissi E, Alvarez C, Lanio M E, Pazos F, Schreier S

Abstract excerpt

Experimental evidence shows that the mechanism of pore formation by actinoporins is a multistep process, involving binding of the water-soluble monomer to the membrane and subsequent oligomerization on the membrane surface, leading to the formation of a functional pore. However, as for other eukaryotic pore-forming toxins, the molecular details of the mechanism of membrane insertion and oligomerization are not...

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PMID: 21510967
DOI: 10.1016/j.toxicon.2011.04.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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