Article
Validation of a mutant of the pore-forming toxin sticholysin-I for the construction of proteinase-activated immunotoxins.
Protein engineering, design & selection : PEDS - 1 Jun 2011
Pentón David, Pérez-Barzaga Victor, Díaz Iscel, Reytor Mey L, Campos Javier, Fando Rafael, Calvo Loany, Cilli Eduardo M, Morera Vivian, Castellanos-Serra Lila R, Pazos Fabiola, Lanio María E, Alvarez Carlos, Pons Tirso, Tejuca Mayra
Abstract excerpt
The use of pore-forming toxins from sea anemones (actinoporins) in the construction of immunotoxins (ITs) against tumour cells is an alternative for cancer therapy. However, the main disadvantage of actinoporin-based ITs obtained so far has been the poor cellular specificity associated with the toxin's ability to bind and exert its activity in almost any cell membrane. Our final goal is the construction of tumour...
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