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Article

Structure-function studies of tryptophan mutants of equinatoxin II, a sea anemone pore-forming protein.

The Biochemical journal - 15 Feb 2000

Malovrh P, Barlic A, Podlesek Z, MaCek P, Menestrina G, Anderluh G

Abstract excerpt

Equinatoxin II (EqtII) is a eukaryotic cytolytic toxin that avidly creates pores in natural and model lipid membranes. It contains five tryptophan residues in three different regions of the molecule. In order to study its interaction with the lipid membranes, three tryptophan mutants, EqtII Trp(45), EqtII Trp(116/117) and EqtII Trp(149), were prepared in an Escherichia coli expression system [here, the tryptophan...

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PMID: 10657261
PMCID: PMC1220844

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