Article
R468A mutation in perfringolysin O destabilizes toxin structure and induces membrane fusion.
Biochimica et biophysica acta. Biomembranes - 1 Jun 2017
Kulma Magdalena, Kacprzyk-Stokowiec Aleksandra, Kwiatkowska Katarzyna, Traczyk Gabriela, Sobota Andrzej, Dadlez Michał
Abstract excerpt
Perfringolysin O (PFO) belongs to the family of cholesterol-dependent cytolysins. Upon binding to a cholesterol-containing membrane, PFO undergoes a series of structural changes that result in the formation of a β-barrel pore and cell lysis. Recognition and binding to cholesterol are mediated by the D4 domain, one of four domains of PFO. The D4 domain contains a conserved tryptophan-rich loop named undecapeptide...
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