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Article

A BMAL1 mutant with arginine 91 substituted with alanine acts as a dominant negative inhibitor.

Gene - 1 Sept 2004

Hosoda Hiroshi, Motohashi Junko, Kato Haruno, Masushige Shoichi, Kida Satoshi

Abstract excerpt

Basic-Helix-Loop-Helix-Per-Arnt-Sim (bHLH-PAS) transcription factor, Brain-Muscle-Arnt-Like-protein 1 (BMAL1), forms a heterodimer with the CLOCK protein. The BMAL1/CLOCK complex binds to a specific DNA sequence and plays an essential role in the generation of the circadian rhythm. The basic region of BMAL1 contains an E-R-X-R motif that is highly conserved among basic-helix-loop-helix (bHLH) transcription...

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Source

Identifiers

PMID: 15315827
DOI: 10.1016/j.gene.2004.05.022

Genes

BMAL1
CLOCK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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A BMAL1 mutant with arginine 91 substituted with alanine acts as a dominant negative inhibitor.PMID 15315827Read ↗

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Phosphorylation of DNA-binding domains of CLOCK-BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells.Semantic proximity Read ↗

BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system.Semantic proximity Read ↗

The Arg-293 of Cryptochrome1 is responsible for the allosteric regulation of CLOCK-CRY1 binding in circadian rhythm.Semantic proximity Read ↗

A Slow Conformational Switch in the BMAL1 Transactivation Domain Modulates Circadian Rhythms.Semantic proximity Read ↗

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