Article
A Slow Conformational Switch in the BMAL1 Transactivation Domain Modulates Circadian Rhythms.
Molecular cell - 18 May 2017
Gustafson Chelsea L, Parsley Nicole C, Asimgil Hande, Lee Hsiau-Wei, Ahlbach Christopher, Michael Alicia K, Xu Haiyan, Williams Owen L, Davis Tara L, Liu Andrew C, Partch Carrie L
Abstract excerpt
The C-terminal transactivation domain (TAD) of BMAL1 (brain and muscle ARNT-like 1) is a regulatory hub for transcriptional coactivators and repressors that compete for binding and, consequently, contributes to period determination of the mammalian circadian clock. Here, we report the discovery of two distinct conformational states that slowly exchange within the dynamic TAD to control timing. This binary switch...
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