Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system.

Genes & development - 1 Aug 2003

Kondratov Roman V, Chernov Mikhail V, Kondratova Anna A, Gorbacheva Victoria Y, Gudkov Andrei V, Antoch Marina P

Abstract excerpt

Mammalian CLOCK and BMAL1 are two members of bHLH-PAS-containing family of transcription factors that represent the positive elements of circadian autoregulatory feedback loop. In the form of a heterodimer, they drive transcription from E-box enhancer elements in the promoters of responsive genes. We have examined abundance, posttranslational modifications, cellular localization of endogenous and ectopically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to ARNTL Transcription Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Basic Helix-Loop-Helix Transcription Factors

Share to Circadian Rhythm

Share to CLOCK Proteins

Share to Dimerization

Share to Oscillometry

Share to Protein Processing, Post-Translational

Source

Open in PubMed Open full text

Identifiers

PMID: 12897057
DOI: 10.1101/gad.1099503
PMCID: PMC196247

Genes

CLOCK
BMAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system.PMID 12897057Read ↗

Role of the CLOCK protein in the mammalian circadian mechanism.Semantic proximity Read ↗

Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription.Semantic proximity Read ↗

Biochemical mechanism of the mammalian circadian clockSemantic proximity Read ↗

Mammalian Period represses and de-represses transcription by displacing CLOCK-BMAL1 from promoters in a Cryptochrome-dependent manner.Semantic proximity Read ↗

A Novel Bmal1 Mutant Mouse Reveals Essential Roles of the C-Terminal Domain on Circadian Rhythms.Semantic proximity Read ↗

Biochemical analysis of the canonical model for the mammalian circadian clock.Semantic proximity Read ↗

Circadian clock control by SUMOylation of BMAL1.Semantic proximity Read ↗

Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulatorSemantic proximity Read ↗

Involvement of CLOCK:BMAL1 heterodimer in serum-responsive mPer1 induction.Semantic proximity Read ↗

Critical Roles of the Circadian Transcription Factor BMAL1 in Reproductive Endocrinology and FertilitySemantic proximity Read ↗

Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival.Semantic proximity Read ↗

Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.