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Article

Mutational scanning identified amino acids of the CLOCK exon 19-domain essential for circadian rhythms.

Acta physiologica (Oxford, England) - 1 Apr 2022

Abdo Ashraf N, Rintisch Carola, Gabriel Christian H, Kramer Achim

Abstract excerpt

AIM: In the mammalian circadian clock, the CLOCK/BMAL1 heterodimer binds to E-box enhancer elements in the promoters of its target genes to activate transcription. The classical Clock mice, the first circadian mouse mutant discovered, are behaviourally arrhythmic. In this mutant, CLOCK lacks a 51 amino acid domain corresponding to exon 19 (CLOCKΔ19), which is required for normal transactivation. While the...

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PMID: 35112498
DOI: 10.1111/apha.13794

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