Article
Involvement of CLOCK:BMAL1 heterodimer in serum-responsive mPer1 induction.
Neuroreport - 20 Jan 2003
Jung Hosung, Choe Youngshik, Kim Hyunjung, Park Noheon, Son Gi Hoon, Khang Inkoo, Kim Kyungjin
Abstract excerpt
A rapid induction of mouse period1 (mPer1) gene expression is supposed to be critical in the clock gene regulation, especially in the phase resetting of the clock, but its molecular mechanism is poorly understood. Based on the previous finding that the process does not involve de novo synthesis of proteins, we postulated the involvement of CLOCK:BMAL1 heterodimer, a positive regulator of circadian oscillator, in...
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