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Article

The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1.

Nature structural & molecular biology - 1 May 2005

Akashi Makoto, Takumi Toru

Abstract excerpt

The PAS (PER-ARNT-SIM) helix-loop-helix transcription factor BMAL1 (also known as MOP3) is an essential component of the circadian pacemaker in mammals. Here we show that the retinoic acid receptor-related orphan receptor RORalpha (NR1F1) directly activates transcription of Bmal1 through two conserved RORalpha response elements that are required for cell-autonomous transcriptional oscillation of Bmal1 mRNA....

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Source

Identifiers

PMID: 15821743
DOI: 10.1038/nsmb925

Genes

ARNT
BMAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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