Article
Phosphorylation of DNA-binding domains of CLOCK-BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America - 4 Jun 2024
Otobe Yuta, Jeong Eui Min, Ito Shunsuke, Shinohara Yuta, Kurabayashi Nobuhiro, Aiba Atsu, Fukada Yoshitaka, Kim Jae Kyoung, Yoshitane Hikari
Abstract excerpt
In mammals, CLOCK and BMAL1 proteins form a heterodimer that binds to E-box sequences and activates transcription of target genes, including Period (Per). Translated PER proteins then bind to the CLOCK-BMAL1 complex to inhibit its transcriptional activity. However, the molecular mechanism and the impact of this PER-dependent inhibition on the circadian clock oscillation remain elusive. We previously identified...
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