Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis.

Oncogene - 30 Oct 2003

Moore Lynette, Venkatachalam Sundaresan, Vogel Hannes, Watt Julie C, Wu Chao-Ling, Steinman Heather, Jones Stephen N, Donehower Lawrence A

Abstract excerpt

The p19ARF gene product responds to oncogenic stresses by interfering with the inhibitory effects of Mdm2 on p53, thus enhancing p53 activity and its antiproliferative functions. The absence of p19ARF in the mouse leads to early tumor susceptibility, presumably in part due to decreased p53 activity. To examine the tumorigenic cooperativity of p19ARF, Mdm2, and p53 in vivo, p19ARF-deficient mice were crossed first...

Topics

Alleles
Animals
Cyclin-Dependent Kinase Inhibitor p16
Genotype
Mice
Mice, Inbred C57BL
Mice, Transgenic
Neoplasms, Experimental
Nuclear Proteins
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-mdm2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Suppressor Protein p14ARF

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 14586409
DOI: 10.1038/sj.onc.1206985

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-14586409-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis.PMID 14586409Read ↗

p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways.Semantic proximity Read ↗

Large-Scale Mutagenesis in p19ARF- and p53-Deficient Mice Identifies Cancer Genes and Their Collaborative NetworksSemantic proximity Read ↗

[When p19ARF finds a partner or new "dangerous liaisons"].Semantic proximity Read ↗

Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development.Semantic proximity Read ↗

Tumor spectrum in ARF-deficient mice.Semantic proximity Read ↗

Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland.Semantic proximity Read ↗

The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis.Semantic proximity Read ↗

p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners.Semantic proximity Read ↗

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis.Semantic proximity Read ↗

The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis.Semantic proximity Read ↗

Cooperating oncogenic events in murine mammary tumorigenesis: assessment of ErbB2, mutant p53, and mouse mammary tumor virus.Semantic proximity Read ↗

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.