Article
Mutant Nrf2E79Q enhances the promotion and progression of a subset of oncogenic Ras keratinocytes and skin tumors.
Redox biology - 1 Sept 2024
Witherspoon John G, Hall Jonathan R, Jima Dereje, Atkins Hannah M, Wamsley Nathan T, Major Michael B, Weissman Bernard E, Smart Robert C
Abstract excerpt
Squamous cell carcinomas (SCCs), including lung, head & neck, bladder, and skin SCCs often display constitutive activation of the KEAP1-NRF2 pathway. Constitutive activation is achieved through multiple mechanisms, including activating mutations in NFE2L2 (NRF2). To determine the functional consequences of Nrf2 activation on skin SCC development, we assessed the effects of mutant Nrf2E79Q expression, one of the...
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