Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Trinucleotide repeat expansions catalyzed by human cell-free extracts.

Cell research - 1 Apr 2013

Stevens Jennifer R, Lahue Elaine E, Li Guo-Min, Lahue Robert S

Abstract excerpt

Trinucleotide repeat expansions cause 17 heritable human neurological disorders. In some diseases, somatic expansions occur in non-proliferating tissues such as brain where DNA replication is limited. This finding stimulated significant interest in replication-independent expansion mechanisms. Aberrant DNA repair is a likely source, based in part on mouse studies showing that somatic expansions are provoked by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell-Free System
Share to DNA Repair
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Biological

Share to MutS DNA Mismatch-Binding Protein

Share to Plasmids

Share to Trinucleotide Repeat Expansion

Source

Open in PubMed Open full text

Identifiers

PMID: 23337586
DOI: 10.1038/cr.2013.12
PMCID: PMC3616437

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Trinucleotide repeat expansions catalyzed by human cell-free extracts.PMID 23337586Read ↗

MutSβ promotes trinucleotide repeat expansion by recruiting DNA polymerase β to nascent (CAG)n or (CTG)n hairpins for error-prone DNA synthesisSemantic proximity Read ↗

The Startling Role of Mismatch Repair in Trinucleotide Repeat Expansions.Semantic proximity Read ↗

DNA mismatch repair complex MutSβ promotes GAA·TTC repeat expansion in human cells.Semantic proximity Read ↗

Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues.Semantic proximity Read ↗

Human MutLγ, the MLH1–MLH3 heterodimer, is an endonuclease that promotes DNA expansionSemantic proximity Read ↗

Fourteen and counting: unraveling trinucleotide repeat diseasesSemantic proximity Read ↗

Repeat instability as the basis for human diseases and as a potential target for therapy.Semantic proximity Read ↗

DNA Triplet Repeat Expansion and Mismatch RepairSemantic proximity Read ↗

Mechanisms of DNA expansion.Semantic proximity Read ↗

Hijacking of the mismatch repair system to cause CAG expansion and cell death in neurodegenerative disease.Semantic proximity Read ↗

Nucleotide excision repair and the 26S proteasome function together to promote trinucleotide repeat expansions.Semantic proximity Read ↗

REV1 inhibition enhances trinucleotide repeat mutagenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.