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Article

Histone deacetylase complexes promote trinucleotide repeat expansions.

PLoS biology - 1 Feb 2012

Debacker Kim, Frizzell Aisling, Gleeson Olive, Kirkham-McCarthy Lucy, Mertz Tony, Lahue Robert S

Abstract excerpt

Expansions of DNA trinucleotide repeats cause at least 17 inherited neurodegenerative diseases, such as Huntington's disease. Expansions can occur at frequencies approaching 100% in affected families and in transgenic mice, suggesting that specific cellular proteins actively promote (favor) expan...

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Identifiers

PMID: 22363205
DOI: 10.1371/journal.pbio.1001257
PMCID: PMC3283555

Genes

HDAC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22363205-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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