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Article

Histone deacetylase complexes promote trinucleotide repeat expansions.

PLoS biology - 1 Feb 2012

Debacker Kim, Frizzell Aisling, Gleeson Olive, Kirkham-McCarthy Lucy, Mertz Tony, Lahue Robert S

Abstract excerpt

Expansions of DNA trinucleotide repeats cause at least 17 inherited neurodegenerative diseases, such as Huntington's disease. Expansions can occur at frequencies approaching 100% in affected families and in transgenic mice, suggesting that specific cellular proteins actively promote (favor) expansions. The inference is that expansions arise due to the presence of these promoting proteins, not their absence, and...

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Identifiers

PMID: 22363205
DOI: 10.1371/journal.pbio.1001257
PMCID: PMC3283555

Genes

HDAC3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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