Article
Characterization and expression of the human WNT4; lack of associated germline mutations in high--to moderate--risk breast and ovarian cancer.
Cancer letters - 15 Sept 2004
Peltoketo Hellevi, Allinen Minna, Vuosku Jaana, Kujala Sonja, Lundan Tuija, Salminen Annamari, Winqvist Robert, Vainio Seppo
Abstract excerpt
Wnt4 is needed for correct development of several tissues in the mouse, and WNT4 is found here to be expressed in a temporal manner in human embryonic tissues. In addition, WNT4 mRNA is seen in several adult tissues. The 1.5 kb transcript is dominant in adult tissues, whereas the 2.4 kb transcript is the major one in embryonic tissues. The involvement of WNT4 in normal mammary gland and ovary development suggests...
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