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Article

WNT4 Balances Development vs Disease in Gynecologic Tissues and Women's Health.

Endocrinology - 1 Jul 2021

Pitzer Lauren M, Moroney Marisa R, Nokoff Natalie J, Sikora Matthew J

Abstract excerpt

The WNT family of proteins is crucial in numerous developmental pathways and tissue homeostasis. WNT4, in particular, is uniquely implicated in the development of the female phenotype in the fetus, and in the maintenance of müllerian and reproductive tissues. WNT4 dysfunction or dysregulation can drive sex-reversal syndromes, highlighting the key role of WNT4 in sex determination. WNT4 is also critical in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33963381
DOI: 10.1210/endocr/bqab093
PMCID: PMC8197283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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