Article

A SNP affects Wnt4 expression in endometrial stroma, with antagonistic implications for pregnancy, endometriosis and reproductive cancers

2022-10-26

Abstract excerpt

The common human single nucleotide polymorphism rs3820282 is associated with multiple phenotypes ranging from gestational length to likelihood of endometriosis and ovarian cancer and can thus serve as a paradigm for a highly pleiotropic genetic variant. Pleiotropy makes it challenging to assign specific causal roles to particular genetic variants. Deleterious mutations in multifunctional genes may cause either the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 299b565a-affa-528e-8078-d4df0d4c132f
DOI: 10.1101/2022.10.25.513653

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A SNP affects Wnt4 expression in endometrial stroma, with antagonistic implications for pregnancy, endometriosis and reproductive cancersDOI 10.1101/2022.10.25.513653Read

A common allele increases endometrial Wnt4 expression, with antagonistic implications for pregnancy, reproductive cancers, and endometriosis.Semantic proximity Read

WNT4 Balances Development vs Disease in Gynecologic Tissues and Women's Health.Semantic proximity Read

Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the <i>WNT4</i> 1p36.12 locusSemantic proximity Read

Transcriptomic Analysis Reveals Intrinsic Abnormalities in Endometrial PolypsSemantic proximity Read

10 Years of GWAS discovery in endometrial cancer: Aetiology, function and translation.Semantic proximity Read

WNT4 (rs7521902 and rs16826658) polymorphism and its association with endometriosis - A systematic review and meta-analysis.Semantic proximity Read

Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.Semantic proximity Read

Identifying the biological basis of GWAS hits for endometriosis.Semantic proximity Read

Unraveling the significance of AGPAT4 for the pathogenesis of endometriosis via a multi-omics approach.Semantic proximity Read

Whole-exome sequencing of endometriosis identifies frequent alterations in genes involved in cell adhesion and chromatin-remodeling complexes.Semantic proximity Read

Endometriosis risk alleles at 1p36.12 act through inverse regulation of CDC42 and LINC00339.Semantic proximity Read