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Article

Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability.

The Journal of cell biology - 23 Mar 2009

Catalucci Daniele, Zhang Deng-Hong, DeSantiago Jaime, Aimond Franck, Barbara Guillaume, Chemin Jean, Bonci Désiré, Picht Eckard, Rusconi Francesca, Dalton Nancy D, Peterson Kirk L, Richard Sylvain, Bers Donald M, Brown Joan Heller, Condorelli Gianluigi

Abstract excerpt

The insulin IGF-1-PI3K-Akt signaling pathway has been suggested to improve cardiac inotropism and increase Ca(2+) handling through the effects of the protein kinase Akt. However, the underlying molecular mechanisms remain largely unknown. In this study, we provide evidence for an unanticipated re...

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Identifiers

PMID: 19307602
DOI: 10.1083/jcb.200805063
PMCID: PMC2699149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19307602-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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