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Article

Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1.

Molecular biology of the cell - 1 Jan 2006

Srivastava Shekhar, Choudhury Papiya, Li Zhai, Liu Gongxin, Nadkarni Vivek, Ko Kyung, Coetzee William A, Skolnik Edward Y

Abstract excerpt

KCa3.1 is an intermediate conductance Ca2+-activated K+ channel that is expressed predominantly in hematopoietic cells, smooth muscle cells, and epithelia where it functions to regulate membrane potential, Ca2+ influx, cell volume, and chloride secretion. We recently found that the KCa3.1 channel also specifically requires phosphatidylinositol-3 phosphate [PI(3)P] for channel activity and is inhibited by...

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Identifiers

PMID: 16251351
DOI: 10.1091/mbc.e05-08-0763
PMCID: PMC1345654

Genes

MTMR6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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