Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1.

doi:10.1091/mbc.e05-08-0763

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Article

Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1.

Molecular biology of the cell - 1 Jan 2006

Srivastava Shekhar, Choudhury Papiya, Li Zhai, Liu Gongxin, Nadkarni Vivek, Ko Kyung, Coetzee William A, Skolnik Edward Y

Abstract excerpt

KCa3.1 is an intermediate conductance Ca2+-activated K+ channel that is expressed predominantly in hematopoietic cells, smooth muscle cells, and epithelia where it functions to regulate membrane potential, Ca2+ influx, cell volume, and chloride secretion. We recently found that the KCa3.1 channel also specifically requires phosphatidylinositol-3 phosphate [PI(3)P] for channel activity and is inhibited by...

Topics

Amino Acid Sequence
Animals
CHO Cells
Cell Membrane
Conserved Sequence
Cricetinae
Cytosol
Electrophysiology
Enzyme Activation
Humans
Intermediate-Conductance Calcium-Activated Potassium Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Patch-Clamp Techniques

Peptide Fragments

Phosphatidylinositol Phosphates

Phosphoric Monoester Hydrolases

Phosphorylation

Source

Open in PubMed Open full text

Identifiers

PMID: 16251351
DOI: 10.1091/mbc.e05-08-0763
PMCID: PMC1345654

Genes

MTMR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16251351-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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