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Article

E-cadherin-mediated adhesion inhibits ligand-dependent activation of diverse receptor tyrosine kinases.

The EMBO journal - 21 Apr 2004

Qian Xiaolan, Karpova Tatiana, Sheppard Allan M, McNally James, Lowy Douglas R

Abstract excerpt

E-cadherin is an essential adhesion protein as well as a tumor suppressor that is silenced in many cancers. Its adhesion-dependent regulation of signaling has not been elucidated. We report that E-cadherin can negatively regulate, in an adhesion-dependent manner, the ligand-dependent activation of divergent classes of receptor tyrosine kinases (RTKs), by inhibiting their ligand-dependent activation in association...

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Identifiers

PMID: 15057284
DOI: 10.1038/sj.emboj.7600136
PMCID: PMC394229

Genes

EGFR
LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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