Article
Prions are a common mechanism for phenotypic inheritance in wild yeasts.
Nature - 15 Feb 2012
Halfmann Randal, Jarosz Daniel F, Jones Sandra K, Chang Amelia, Lancaster Alex K, Lindquist Susan
Abstract excerpt
The self-templating conformations of yeast prion proteins act as epigenetic elements of inheritance. Yeast prions might provide a mechanism for generating heritable phenotypic diversity that promotes survival in fluctuating environments and the evolution of new traits. However, this hypothesis is highly controversial. Prions that create new traits have not been found in wild strains, leading to the perception...
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