Prions are a common mechanism for phenotypic inheritance in wild yeasts.

doi:10.1038/nature10875

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Article

Prions are a common mechanism for phenotypic inheritance in wild yeasts.

Nature - 15 Feb 2012

Halfmann Randal, Jarosz Daniel F, Jones Sandra K, Chang Amelia, Lancaster Alex K, Lindquist Susan

Abstract excerpt

The self-templating conformations of yeast prion proteins act as epigenetic elements of inheritance. Yeast prions might provide a mechanism for generating heritable phenotypic diversity that promotes survival in fluctuating environments and the evolution of new traits. However, this hypothesis is highly controversial. Prions that create new traits have not been found in wild strains, leading to the perception...

Topics

Biological Evolution
Cell Wall
Cytoplasm
Epigenesis, Genetic
Genetic Association Studies
Genetic Variation
Genotype
Heat-Shock Proteins
Laboratories
Meiosis
Peptide Termination Factors
Phenotype
Prions
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 22337056
DOI: 10.1038/nature10875
PMCID: PMC3319070

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