Article
Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia.
Psychiatric genetics - 1 Jun 2003
Fujii Yo, Shibata Hiroki, Kikuta Rumiko, Makino Chieko, Tani Ayako, Hirata Naotsugu, Shibata Atsushi, Ninomiya Hideaki, Tashiro Nobutada, Fukumaki Yasuyuki
Abstract excerpt
OBJECTIVES: Glutamatergic dysfunction is one of the major hypotheses of schizophrenia pathophysiology. We have been conducting systematic studies on the association between glutamate receptors and schizophrenia. We focused on the metabotropic glutamate receptor type 3 gene (GRM3) as a candidate for schizophrenia susceptibility. METHODS: We genotyped Japanese schizophrenics (n=100) and controls (n=100) for six...
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