Mutation of the high affinity calcium binding sites in cardiac troponin C.

Article

Mutation of the high affinity calcium binding sites in cardiac troponin C.

The Journal of biological chemistry - 15 Jan 1992

Negele J C, Dotson D G, Liu W, Sweeney H L, Putkey J A

Abstract excerpt

Fast skeletal and cardiac troponin C (TnC) contain two high affinity Ca2+/Mg2+ binding sites within the C-terminal domain that are thought to be important for association of TnC with the troponin complex of the thin filament. To test directly the function of these high affinity sites in cardiac T...

Topics

Adenosine Triphosphatases
Amino Acid Sequence
Animals
Base Sequence
Binding Sites
Calcium
Female
Molecular Sequence Data
Muscles
Mutagenesis, Site-Directed
Mutation
Myocardium
Rabbits
Troponin
Troponin C

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