Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation of the high affinity calcium binding sites in cardiac troponin C.

The Journal of biological chemistry - 15 Jan 1992

Negele J C, Dotson D G, Liu W, Sweeney H L, Putkey J A

Abstract excerpt

Fast skeletal and cardiac troponin C (TnC) contain two high affinity Ca2+/Mg2+ binding sites within the C-terminal domain that are thought to be important for association of TnC with the troponin complex of the thin filament. To test directly the function of these high affinity sites in cardiac TnC they were systematically altered by mutagenesis to generate proteins with a single inactive site III or IV (CBM-III...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Binding Sites

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Calcium

Share to Molecular Sequence Data

Share to Mutagenesis, Site-Directed

Share to Mutation

Share to Rabbits

Source

Identifiers

PMID: 1530938

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of the high affinity calcium binding sites in cardiac troponin C.PMID 1530938Read ↗

Troponin-C mutants with increased calcium affinity.Semantic proximity Read ↗

Differential recovery of Ca2+ binding activity in mutated EF-hands of cardiac troponin C.Semantic proximity Read ↗

Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments.Semantic proximity Read ↗

Function of the N-terminal calcium-binding sites in cardiac/slow troponin C assessed in fast skeletal muscle fibers.Semantic proximity Read ↗

Calcium affinity of regulatory sites in skeletal troponin-C is attenuated by N-cap mutations of helix C.Semantic proximity Read ↗

Enhanced troponin I binding explains the functional changes produced by the hypertrophic cardiomyopathy mutation A8V of cardiac troponin C.Semantic proximity Read ↗

Basic residues within the cardiac troponin T C terminus are required for full inhibition of muscle contraction and limit activation by calcium.Semantic proximity Read ↗

Engineered troponin C constructs correct disease-related cardiac myofilament calcium sensitivity.Semantic proximity Read ↗

Modulation of the rate of cardiac muscle contraction by troponin C constructs with various calcium binding affinities.Semantic proximity Read ↗

Sequence mutations in teleost cardiac troponin C that are permissive of high Ca2+ affinity of site II.Semantic proximity Read ↗

Troponin C Mutations Partially Stabilize the Active State of Regulated Actin and Fully Stabilize the Active State When Paired with Δ14 TnT.Semantic proximity Read ↗

Characterisation of a mutant of barnacle troponin C lacking Ca2+-binding sites at positions II and IV.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.