Function of the N-terminal calcium-binding sites in cardiac/slow troponin C assessed in fast skeletal muscle fibers.

Article

Function of the N-terminal calcium-binding sites in cardiac/slow troponin C assessed in fast skeletal muscle fibers.

The Journal of biological chemistry - 15 Aug 1991

Putkey J A, Liu W, Sweeney H L

Abstract excerpt

Fast skeletal troponin C (sTnC) has two low affinity Ca(2+)-binding sites (sites I and II), whereas in cardiac troponin C (cTnC) site I is inactive. By modifying the Ca2+ binding properties of sites I and II in cTnC it was demonstrated that binding of Ca2+ to an activated site I alone is not suff...

Topics

Amino Acid Sequence
Animals
Binding Sites
Calcium
Female
Molecular Sequence Data
Muscles
Mutation
Myocardium
Protein Conformation
Rabbits
Recombinant Proteins
Troponin
Troponin C

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