Article
Down syndrome (DS) peripheral blood contains phenotypically mature CD3+TCR alpha, beta+ cells but abnormal proportions of TCR alpha, beta+, TCR gamma, delta+, and CD4+ CD45RA+ cells: evidence for an inefficient release of mature T cells by the DS thymus.
Clinical immunology and immunopathology - 1 Feb 1992
Murphy M, Epstein L B
Abstract excerpt
Down syndrome (DS) thymocytes have a markedly diminished proportion of cells expressing high levels of the alpha, beta T cell receptor (TCR alpha, beta) and the associated CD3 molecule. Thus, we examined the surface expression of TCR alpha, beta and CD3 as well as TCR gamma, delta, CD4, CD8, CD16...
Topics
- Adolescent
- Adult
- Antigens, CD
- Antigens, Differentiation
- Antigens, Differentiation, T-Lymphocyte
- CD3 Complex
- CD4 Antigens
- CD8 Antigens
- Child
- Child, Preschool
- Down Syndrome
- Eosinophils
- Histocompatibility Antigens
- Humans