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Article

Defective thymic progenitor development and mature T-cell responses in a mouse model for Down syndrome.

Immunology - 1 Aug 2013

Lorenzo Laureanne P E, Shatynski Kristen E, Clark Sarah, Yarowsky Paul J, Williams Mark S

Abstract excerpt

In addition to archetypal cognitive defects, Down syndrome (DS) is characterized by altered lymphocyte development and function, including premature thymic involution and increased incidence of infections. However, the potential mechanisms for these changes have not been fully elucidated. The current study used the Ts65Dn mouse model of DS to assess deficiencies in T-cell development and possible molecular...

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Identifiers

PMID: 23432468
DOI: 10.1111/imm.12092
PMCID: PMC3719062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Defective thymic progenitor development and mature T-cell responses in a mouse model for Down syndrome.PMID 23432468Read ↗

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Primary and secondary defects of the thymusSemantic proximity Read ↗

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