Article
Intrathymic deficient expansion of T cell precursors in Down syndrome.
American journal of medical genetics. Supplement - 1 Jan 1990
Musiani P, Valitutti S, Castellino F, Larocca L M, Maggiano N, Piantelli M
Abstract excerpt
To correlate the intrinsic cellular immunodeficiency, which is a major cause of increased susceptibility to polytopic infections in Down syndrome (DS) patients, with the histologic abnormalities observed in the thymus of these patients, we have studied thymus fragments and thymocyte cell suspensions from 15 non-institutionalized DS subjects. Comparing to the control age-matched samples, a reduced thymic cortex...
Topics
- Child, Preschool
- Down Syndrome
- Humans
- Infant
- Phenotype
- Receptors, Antigen, T-Cell
- T-Lymphocyte Subsets
- T-Lymphocytes
- Thymus Gland