Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Prevalent CXCR3+ Phenotype of Circulating Follicular Helper T Cells Indicates Humoral Dysregulation in Children with Down Syndrome.

Journal of clinical immunology - 1 Apr 2020

Ottaviano Giorgio, Gerosa Jolanda, Santini Micaela, De Leo Pasqualina, Vecchione Andrea, Jofra Tatiana, Trimarchi Cristiana, De Pellegrin Maurizio, Agosti Massimo, Aiuti Alessandro, Marinoni Maddalena, Cicalese Maria Pia, Fousteri Georgia

Abstract excerpt

Patients with Down syndrome (DS) are characterized by increased susceptibility to autoimmunity and respiratory tract infections that are suggestive of humoral immunity impairment. Here, we sought to determine the follicular helper (Tfh) and follicular regulatory (Tfr) T cell profile in the blood of children with DS. Blood was collected from 24 children with DS, nine of which had autoimmune diseases. Children with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Diseases
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Down Syndrome

Share to Germinal Center

Share to Immunity, Humoral

Share to Receptors, CXCR3

Share to T-Lymphocyte Subsets

Share to T-Lymphocytes, Helper-Inducer

Source

Identifiers

PMID: 31993866
DOI: 10.1007/s10875-020-00755-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Prevalent CXCR3+ Phenotype of Circulating Follicular Helper T Cells Indicates Humoral Dysregulation in Children with Down Syndrome.PMID 31993866Read ↗

The immune system in Down Syndrome: Autoimmunity and severe infections.Semantic proximity Read ↗

Immune Defect in Adults With Down Syndrome: Insights Into a Complex Issue.Semantic proximity Read ↗

Quantitative, Phenotypical, and Functional Characterization of Cellular Immunity in Children and Adolescents With Down Syndrome.Semantic proximity Read ↗

Down syndrome, autoimmunity and T regulatory cells.Semantic proximity Read ↗

Altered Expression of Immune-Related Genes in Children with Down SyndromeSemantic proximity Read ↗

Progressive deterioration of adaptive immune repertoires in Down syndrome linked to interferon hyperactivity and lymphoid tissue disorganizationSemantic proximity Read ↗

Down syndrome (DS) peripheral blood contains phenotypically mature CD3+TCR alpha, beta+ cells but abnormal proportions of TCR alpha, beta+, TCR gamma, delta+, and CD4+ CD45RA+ cells: evidence for an inefficient release of mature T cells by the DS thymus.Semantic proximity Read ↗

Development of an effective immune response in adults with Down Syndrome after SARS-CoV-2 vaccinationSemantic proximity Read ↗

T Lymphocyte Maturation Is Impaired in Healthy Young Individuals Carrying Trisomy 21 (Down Syndrome)Semantic proximity Read ↗

Altered pro-inflammatory and anti-inflammatory plasma cytokines levels in children with Down’s syndromeSemantic proximity Read ↗

Significant decreased CXCR3+ phenotype Tfh1 cells in three Good's syndrome patients.Semantic proximity Read ↗

De novo variants in immune regulatory genes in Down syndrome regression disorderSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.