Article
Quantitative, Phenotypical, and Functional Characterization of Cellular Immunity in Children and Adolescents With Down Syndrome.
The Journal of infectious diseases - 15 May 2017
Schoch Justine, Rohrer Tilman R, Kaestner Michael, Abdul-Khaliq Hashim, Gortner Ludwig, Sester Urban, Sester Martina, Schmidt Tina
Abstract excerpt
Background: Infections and autoimmune disorders are more frequent in Down syndrome, suggesting abnormality of adaptive immunity. Although the role of B cells and antibodies is well characterized, knowledge regarding T cells is limited. Methods: Lymphocyte subpopulations of 40 children and adolescents with Down syndrome and 51 controls were quantified, and phenotype and functionality of antigen-specific effector T...
Topics
- Adolescent
- Antibodies, Viral
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Case-Control Studies
- Child
- Cytomegalovirus
- Down Syndrome
- Female
- Herpesvirus 3, Human
- Humans
- Immunity, Cellular
- Male
- Phenotype