Article
Precocious aging of the immune system in Down syndrome: alteration of B lymphocytes, T-lymphocyte subsets, and cells with natural killer markers.
American journal of medical genetics. Supplement - 1 Jan 1990
Cossarizza A, Monti D, Montagnani G, Ortolani C, Masi M, Zannotti M, Franceschi C
Abstract excerpt
Phenotype and proliferative ability of peripheral blood lymphocytes from 15 noninstitutionalized children affected with Down Syndrome (DS), in apparently good health, were studied and compared with those of 16 healthy control children of the same age. A complex derangement of all the major periph...
Topics
- Adolescent
- Aging
- Antibodies, Monoclonal
- B-Lymphocytes
- Biomarkers
- Cell Division
- Cells, Cultured
- Child
- Child, Preschool
- Down Syndrome
- Humans
- Killer Cells, Natural
- Leukocyte Count
- Lymphocyte Activation
- Phenotype
- T-Lymphocyte Subsets