Article
Alpha(1,3)fucosyltransferases FucT-IV and FucT-VII control susceptibility to atherosclerosis in apolipoprotein E-/- mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2004
Homeister Jonathon W, Daugherty Alan, Lowe John B
Abstract excerpt
OBJECTIVE: These studies examine the contributions of alpha(1,3)fucosyltransferases (FucT) IV and VII to the generation of selectin counter-receptors necessary for selectin-dependent atherogenesis. They also determine the functional contribution of FucT-IV and FucT-VII to shear-dependent tethering of monocytes to P-selectin, a process believed to be required for atherogenesis. METHODS AND RESULTS: Atherosclerotic...
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