Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.

doi:10.1073/pnas.0507375102

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Article

Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 2005

Wang Xiangchun, Inoue Shinya, Gu Jianguo, Miyoshi Eiji, Noda Katsuhisa, Li Wenzhe, Mizuno-Horikawa Yoko, Nakano Miyako, Asahi Michio, Takahashi Motoko, Uozumi Naofumi, Ihara Shinji, Lee Seung Ho, Ikeda Yoshitaka, Yamaguchi Yukihiro, Aze Yoshiya, Tomiyama Yoshiaki, Fujii Junichi, Suzuki Keiichiro, Kondo Akihiro, Shapiro Steven D, Lopez-Otin Carlos, Kuwaki Tomoyuki, Okabe Masaru, Honke Koichi, Taniguchi Naoyuki

Abstract excerpt

The core fucosylation (alpha1,6-fucosylation) of glycoproteins is widely distributed in mammalian tissues, and is altered under pathological conditions. To investigate physiological functions of the core fucose, we generated alpha1,6-fucosyltransferase (Fut8)-null mice and found that disruption of Fut8 induces severe growth retardation and death during postnatal development. Histopathological analysis revealed...

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PMID: 16236725
DOI: 10.1073/pnas.0507375102
PMCID: PMC1257418

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