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Article

Phenotype changes of Fut8 knockout mouse: core fucosylation is crucial for the function of growth factor receptor(s).

Methods in enzymology - 1 Jan 2006

Wang Xiangchun, Gu Jianguo, Miyoshi Eiji, Honke Koichi, Taniguchi Naoyuki

Abstract excerpt

Alpha1,6-fucosyltransferase (Fut8) catalyzes the transfer of a fucose residue to N-linked oligosaccharides on glycoproteins by means of an alpha1,6-linkage to form core fucosylation in mammals. In mice, disruption of Fut8 induces severe growth retardation, early death during postnatal development, and emphysema-like changes in the lung. A marked dysregulation of TGF-beta1 receptor activation and signaling in...

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Source

Identifiers

PMID: 17132494
DOI: 10.1016/S0076-6879(06)17002-0

Genes

EGF
MMP12
MMP13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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