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Article

Conditional control of selectin ligand expression and global fucosylation events in mice with a targeted mutation at the FX locus.

The Journal of cell biology - 19 Aug 2002

Smith Peter L, Myers Jay T, Rogers Clare E, Zhou Lan, Petryniak Bronia, Becker Daniel J, Homeister Jonathon W, Lowe John B

Abstract excerpt

Glycoprotein fucosylation enables fringe-dependent modulation of signal transduction by Notch transmembrane receptors, contributes to selectin-dependent leukocyte trafficking, and is faulty in leukocyte adhesion deficiency (LAD) type II, also known as congenital disorder of glycosylation (CDG)-IIc, a rare human disorder characterized by psychomotor defects, developmental abnormalities, and leukocyte adhesion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12186857
DOI: 10.1083/jcb.200203125
PMCID: PMC2174027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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