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Article

Genetic variation in proinflammatory cytokines IL6, IL6R, TNF-region, and TNFRSF1A and risk of breast cancer.

Breast cancer research and treatment - 1 Oct 2011

Madeleine Margaret M, Johnson Lisa G, Malkki Mari, Resler Alexa J, Petersdorf Effie W, McKnight Barbara, Malone Kathleen E

Abstract excerpt

Proinflammatory cytokines are associated with age-related diseases including arthritis and heart disease. IL6 and TNF also play key roles in estrogen modulation in older women. We explored whether variation in IL6 and TNF genes influenced the risk of breast cancer in samples that differed by age group: <44 years (228 cases and 271 controls), 45-64 years (426 cases and 396 controls), and 65+ years (228 cases and...

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Identifiers

PMID: 21523452
DOI: 10.1007/s10549-011-1520-4
PMCID: PMC3164911

Genes

TNF
LTA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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