Article
Maternal beta-catenin and E-cadherin in mouse development.
Development (Cambridge, England) - 1 Sept 2004
De Vries Wilhelmine N, Evsikov Alexei V, Haac Bryce E, Fancher Karen S, Holbrook Andrea E, Kemler Rolf, Solter Davor, Knowles Barbara B
Abstract excerpt
The oocyte to embryo transition in metazoans depends on maternal proteins and transcripts to ensure the successful initiation of development, and the correct and timely activation of the embryonic genome. We conditionally eliminated the maternal gene encoding the cell adhesion molecule E-cadherin and partially eliminated the beta-catenin gene from the mouse oocyte. Oocytes lacking E-cadherin, or expressing a...
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