Article
β-catenin-mediated adhesion is required for successful preimplantation mouse embryo development.
Development (Cambridge, England) - 1 Jun 2016
Messerschmidt Daniel, de Vries Wilhelmine N, Lorthongpanich Chanchao, Balu Sathish, Solter Davor, Knowles Barbara B
Abstract excerpt
β-catenin (CTNNB1) is integral to cell adhesion and to the canonical Wnt signaling pathway. The effects of maternal and zygotic CTNNB1 on embryogenesis have each been separately assessed, whereas the effect of its total absence has not. As the 'traditional' conditional Ctnnb1 knockout alleles give rise to truncated CTNNB1 fragments, we designed a new knockout allele incapable of CTNNB1 production. Mouse embryos...
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