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Article

A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 1995

Riethmacher D, Brinkmann V, Birchmeier C

Abstract excerpt

The Ca(2+)-dependent cell adhesion molecule E-cadherin functions in the establishment and maintenance of epithelial cell morphology during embryogenesis and adulthood. Downregulation or complete shut-down of E-cadherin expression and mutation of the gene are observed during the progression of tumors of epithelial origin (carcinomas) and correlate with the metastatic potential. We have introduced a targeted...

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Identifiers

PMID: 7846066
DOI: 10.1073/pnas.92.3.855
PMCID: PMC42719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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