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Article

A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 1995

Riethmacher D, Brinkmann V, Birchmeier C

Abstract excerpt

The Ca(2+)-dependent cell adhesion molecule E-cadherin functions in the establishment and maintenance of epithelial cell morphology during embryogenesis and adulthood. Downregulation or complete shut-down of E-cadherin expression and mutation of the gene are observed during the progression of tum...

Topics

Animals
Base Sequence
Blastocyst
Blastomeres
Cadherins
Chimera
Desmosomes
Embryonic and Fetal Development
Gene Targeting
Homozygote
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Molecular Sequence Data

Morula

Mutation

Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 7846066
DOI: 10.1073/pnas.92.3.855
PMCID: PMC42719

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7846066-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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