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Article

Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast.

Development (Cambridge, England) - 1 Dec 2004

Kemler Rolf, Hierholzer Andreas, Kanzler Benoît, Kuppig Stefan, Hansen Kati, Taketo Makoto M, de Vries Wilhelmine N, Knowles Barbara B, Solter Davor

Abstract excerpt

Many components of the Wnt/beta-catenin signaling pathway are expressed during mouse pre-implantation embryo development, suggesting that this pathway may control cell proliferation and differentiation at this time. We find no evidence for a functional activity of this pathway in cleavage-stage embryos using the Wnt-reporter line, BAT-gal. To further probe the activity of this pathway, we activated beta-catenin...

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PMID: 15525667
DOI: 10.1242/dev.01458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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